Placental Insufficiency.
نویسنده
چکیده
منابع مشابه
The role of homeobox genes in the development of placental insufficiency.
Intrauterine growth restriction (IUGR) is an adverse pregnancy outcome associated with significant perinatal and pediatric morbidity and mortality, and an increased risk of chronic disease later in adult life. While a number of maternal, fetal and environmental factors are known causes of IUGR, the majority of IUGR cases are of unknown cause. These IUGR cases are frequently associated with plac...
متن کاملUteroplacental insufficiency impairs PTHrP and growth UTEROPLACENTAL RESTRICTION IN THE RAT IMPAIRS FETAL GROWTH IN ASSOCIATION WITH ALTERATIONS IN PLACENTAL GROWTH FACTORS INCLUDING PTHrP
During pregnancy parathyroid hormone-related protein (PTHrP) is one of many growth factors that play important roles to promote fetal growth and development including stimulating placental calcium transport. Angiotensin II, acting through the AT1a, receptor is also known to promote placental growth. We examined the effects of bilateral uterine artery and vein ligation (Restricted), which mimics...
متن کاملUteroplacental restriction in the rat impairs fetal growth in association with alterations in placental growth factors including PTHrP.
During pregnancy, parathyroid hormone-related protein (PTHrP) is one of many growth factors that play important roles to promote fetal growth and development, including stimulation of placental calcium transport. Angiotensin II, acting through the AT(1a) receptor, is also known to promote placental growth. We examined the effects of bilateral uterine artery and vein ligation (restriction), whic...
متن کاملMaternal Choline Supplementation Alters Fetal Growth Patterns in a Mouse Model of Placental Insufficiency
Impairments in placental development can adversely affect pregnancy outcomes. The bioactive nutrient choline may mitigate some of these impairments, as suggested by data in humans, animals, and human trophoblasts. Herein, we investigated the effects of maternal choline supplementation (MCS) on parameters of fetal growth in a Dlx3+/- (distal-less homeobox 3) mouse model of placental insufficienc...
متن کاملPlacental damages in preeclampsia – from ultrasound images to histopathological findings
Preeclampsia is a unique pregnancy-related disease that affects 5-7% pregnancies worldwide. Placental architecture is modified in PE and eclampsia. Placental morphology and cellular arrangement are important for oxygen delivery from the mother to the fetus. Fetal growth and well-being after 20 weeks of gestation are dependent upon successful placental development. This, in turn, is achieved by ...
متن کاملIncreased Umbilical Cord PAI-1 Levels in Placental Insufficiency Are Associated with Fetal Hypoxia and Angiogenesis
In intrauterine growth restriction (IUGR), a subset of pregnancies undergoes placental vascular dysregulation resulting in restricted blood flow and fetal hypoxemia. Altered transcription of hypoxic regulated plasminogen activator inhibitor 1 (PAI-1) has been associated with pregnancy complications and angiogenic regulation. Here we assessed circulating PAI-1 as an indicator of placental insuff...
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ورودعنوان ژورنال:
- Anales de la Real Academia Nacional de Medicina
دوره 102 1 شماره
صفحات -
تاریخ انتشار 1962